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Video: Primary Immunodeficiency Beyond Infections - Dr Charlotte Cunningham-Rundles, MD, PhD

Primary immunodeficiencies (PI) are a group of rare chronic conditions. There are over 450 PIs already discovered, and they are reported to occur in about one out of every 1,200 people. In this video, Charlotte Cunningham-Rundles, MD, PhD, Professor of Immunology at the Mount Sinai School of Medicine in New York, describes the infectious and non-infectious complications of primary immunodeficiency.

00:00 What are primary immunodeficiencies (PI)?

03:00 Categories of PI

05:21 Prevalence of the categories of PI

06:11 The non-infectious complications of PI

08:51 Pulmonary disease in PI

10:33 Gastrointestinal disease in patients with PI

11:22 Fatigue in patients with PI

12:12 Contributing causes of mortality in patients with PI

13:00 Common Variable Immune Deficiency (CVID) & gastrointestinal complications

15:15 Liver disease in PI

16:32 Comorbidities and mortality in CVID

17:57 Why are there so many complications in PI?

19:24 The burden of disease in PI

PI is also referred to as an Inborn Error of Immunity (IEI).

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