Primary immunodeficiencies (PI) are a group of rare chronic conditions. There are over 450 PIs already discovered, and they are reported to occur in about one out of every 1,200 people. In this video, Charlotte Cunningham-Rundles, MD, PhD, Professor of Immunology at the Mount Sinai School of Medicine in New York, describes the infectious and non-infectious complications of primary immunodeficiency.
00:00 – What are primary immunodeficiencies (PI)?
03:00 – Categories of PI
05:21 – Prevalence of the categories of PI
06:11 – The non-infectious complications of PI
08:51 – Pulmonary disease in PI
10:33 – Gastrointestinal disease in patients with PI
11:22 – Fatigue in patients with PI
12:12 – Contributing causes of mortality in patients with PI
13:00 – Common Variable Immune Deficiency (CVID) & gastrointestinal complications
15:15 – Liver disease in PI
16:32 – Comorbidities and mortality in CVID
17:57 – Why are there so many complications in PI?
19:24 – The burden of disease in PI